Successful heart surgery at We Care India partner hospital allows Robert Clarke to live a normal life despite a rare genetic disorder We Care india helped Robert find best super specialised surgeon for his rare condition.
Lupus nephritis is a kidney disorder that is a complication of systemic lupus erythematosus , characterized by damage to the glomerulus and progressive loss of kidney function.
Causes, incidence, and risk factors
Lupus nephritis is one complication of?systemic lupus erythematosus ( SLE ). It is related to the autoimmune process of lupus, where the immune system produces antibodies ( antinuclear antibody and others) against body components. Complexes of these antibodies and complement accumulate in the kidneys and result in an inflammatory response .
Lupus causes various disorders of the internal structures of the kidney, including interstitial nephritis , mesangial GN, membranous GN , membranoproliferative GN, diffuse proliferative GN, and others.
It often causes nephrotic syndrome (excessive protein excretion) and may progress rapidly to renal failure . There is progressive azotemia (the accumulation of nitrogenous waste products in the bloodstream) and urinary abnormalities including protein and blood in the urine .
Lupus nephritis affects approximately 3 out of 10,000 people. Systemic lupus erythematosus is most common in women 20-40 years old. It runs in families and is more common in blacks. It may be related to other autoimmune disorders including rheumatoid arthritis and scleroderma . It has been known to be triggered by pregnancy in some cases.
In children with SLE, about half will have some form or degree of kidney involvement.
Symptoms
Blood in the urine
Foamy appearance to urine
Swelling of any area of the body
Elevated blood pressure
Symptoms of SLE may include the following : -
Joint pain
Joint swelling
Joint redness
Rash
commonly on the face but may occur on other areas
characteristic "butterfly" distribution
Chest pain , sharp and stabbing
Cough
Sun sensitivity
fever may develop after exposure to sun
rash may develop after exposure to sun
Fatigue
Mouth ulcers (painless)
Neurologic changes
seizures
dementia or psychosis
Signs and tests
Examination indicates decreased kidney functioning with edema and may indicate?kidney failure. Blood pressure may be high. Abnormal sounds may be heard when the doctor listens to the heart and lungs, indicating fluid overload.
Lupus nephritis is usually discovered during investigation of the causes of reduced kidney function. Fewer than half?of patients?have other symptoms of?SLE at the time of diagnosis of lupus nephritis.
A urinalysis is abnormal with protein , casts , and red blood cells present in the urine.
An ANA titer is high.
Syphilis tests may be falsely positive.
BUN and creatinine may be used to assess kidney functioning.
A lupus erythematosus (LE) cell test is positive.
A kidney biopsy is indicated, not to diagnose lupus nephritis, but to determine what
treatment is appropriate for the renal component of SLE.
A urine immunoglobulin light chain is elevated.
This disease may also alter the results of the following tests : -
Complement component 3
Complement
Treatment
The goal of treatment is improvement of kidney function. Corticosteroids or other immunosuppressive medications are often effective in reducing symptoms. Whether high doses of corticosteroids or immunosuppressives are likely to be beneficial depends on the precise findings on kidney biopsy .
Dialysis may be necessary to control symptoms of acute or chronic renal failure . Renal failure may be severe enough to require dialysis even if no other symptoms of SLE are present.
A kidney transplant may be recommended to treat kidney failure resulting from lupus nephritis.
Support Groups
Expectations (prognosis)
The outcome varies. It is usually worse with diffuse proliferative lupus nephritis (one specific form of the disorder). As with SLE , the course is variable, with exacerbations ( acute episodes) and remissions (symptom-free periods). Some cases of lupus nephritis may progress to chronic renal failure .
Although lupus nephritis may recur in a transplanted kidney, it rarely leads to end stage renal disease. People with active lupus should not undergo transplantation.
Complications
Acute renal failure
Chronic renal failure
End-stage renal disease
Nephrotic syndrome
Calling your health care provider
Call your health care provider if blood in the urine or swelling of the body develops.If you have lupus nephritis, call your health care provider if there is decreased urine output .
For more information, medical assessment and medical quote
send your detailed medical history and medical reports
as email attachment to
Email : - info@wecareindia.com
Call: +91 9029304141 (10 am. To 8 pm. IST)
(Only for international patients seeking treatment in India)
For a detailed evaluation send patient’s medical reports / X rays / doctors notes to info@wecareindia.com
This information is not designed to replace a physician's independent judgment about the appropriateness or risks of a procedure for a given patient.
Always consult your doctor about your medical conditions. We Care Health Services does not provide medical advice, diagnosis or treatment. Use of the wecareindia.com site is conditional upon your acceptance of our Terms and Conditions
Call : +91 9029304141 Powered by wecareindia.com
We Care Health Services - India – Mumbai (Bombay), Chennai (Madras), Hyderabad, Kokatta, Delhi, Bangalore.
Best viewed with 1024x720
Lupus Nephritis Treatment India, Price Lupus Nephritis Treatment Delhi, Cost Lupus Nephritis, Lupus Nephritis Treatment Delhi India, Lupus Nephritis Treatment Bangalore India, Lupus Nephritis Treatment Price, Best Lupus Nephritis Treatment Hospital India, Lupus Erythematosus, Symptoms, Lupus Nephritis Treatment Cause, Lupus Nephritis Treatment Hospital Delhi India, Low Cost Lupus Nephritis Treatment India, Lupus Nephritis Treatment Specialist Mumbai India, Lupus Nephritis Treatment Surgeons Bangalore India, Kidney Diseases, Systemic Lupus Erythematosus,, Systemic Lupus Erythematosus, Lupus Nephritis Treatment Doctor India, Lupus Nephritis Treatment Doctors Mumbai India, Mesangial Lupus Nephritis, Membranous Lupus Nephritis, Active Nephritis, Sclerosing Lupus Nephritis
